To contribute to knowledge about SMON and drug-induced diseases, to keep SMON from being forgotten, and to contribute to the medical care and welfare of SMON patients

What is SMON?

Subacute myelo-optico-neuropathy (SMON) is a neurological disease characterized by abdominal symptoms such as stomachache and diarrhea, followed by specific numbness starting at the toe and ascending throughout the lower extremities or to the chest/abdominal area. In addition to such sensory impairments, SMON causes lower limb cramps (spasticity) or weakness, and in severe cases may lead to blindness due to impaired visual acuity or even death in some cases from brain-stem disorder. SMON often occurred in Japan since 1956 and became a social problem because it was suspected to be a new infectious disease and it occurred concurrently in various locations. We hope that this website will be helpful in preventing knowledge about SMON and drug-induced diseases from being forgotten, and facilitate the medical care and welfare of SMON patients.


Research Committee on SMON
Research representative:
Masaaki Konagaya, Director, NHO Suzuka National Hospital
3-2-1 Kasado, Suzuka-shi, Mie-ken, 513-8501
Phone: +81-59-378-1321

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